Martin J Gunthorpe : rechercher sur Z-Library

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1

Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)

Fergal N McNamara, Andrew Randall, Martin J Gunthorpe

Journal:

British Journal of Pharmacology

Année:

2005

Langue:

english

Fichier:

PDF, 262 KB

english, 2005

2

An animal model of chronic inflammatory pain: Pharmacological and temporal differentiation from acute models

Alex W. Wilson, Stephen J. Medhurst, Claire I. Dixon, Nick C. Bontoft, Lisa A. Winyard, Kim T. Brackenborough, Jorge De Alba, Christopher J. Clarke, Martin J. Gunthorpe, Gareth A. Hicks, Chas Bountra,

Journal:

European Journal of Pain

Année:

2006

Langue:

english

Fichier:

PDF, 462 KB

english, 2006

3

The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy

Martin J. Gunthorpe, Charles H. Large, Raman Sankar

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 654 KB

english, 2012

4

Discovery of small molecule antagonists of TRPV1

Harshad K Rami, Mervyn Thompson, Paul Wyman, Jeffrey C Jerman, Julie Egerton, Stephen Brough, Alexander J Stevens, Andrew D Randall, Darren Smart, Martin J Gunthorpe, John B Davis

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 339 KB

english, 2004

5

Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development

Harshad K. Rami, Mervyn Thompson, Geoffrey Stemp, Steve Fell, Jeffrey C. Jerman, Alexander J. Stevens, Darren Smart, Becky Sargent, Dominic Sanderson, Andrew D. Randall, Martin J. Gunthorpe, John B. D

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 290 KB

english, 2006

6

Diltiazem causes open channel block of recombinant 5-HT3 receptors

Martin J. Gunthorpe, Sarah C. R. Lummis

Journal:

The Journal of Physiology

Année:

1999

Langue:

english

Fichier:

PDF, 217 KB

english, 1999

7

The 4′lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-HT3A receptors

Martin J. Gunthorpe, John A. Peters, Catherine H. Gill, Jeremy J. Lambert, Sarah C. R. Lummis

Journal:

The Journal of Physiology

Année:

2000

Langue:

english

Fichier:

PDF, 248 KB

english, 2000

8

Voltage- and time-dependent properties of the recombinant rat vanilloid receptor (rVR1)

Martin J. Gunthorpe, Mark H. Harries, Rab K. Prinjha, John B. Davis, Andrew Randall

Journal:

The Journal of Physiology

Année:

2000

Langue:

english

Fichier:

PDF, 248 KB

english, 2000

9

Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential

Laetitia Mony, James NC Kew, Martin J Gunthorpe, Pierre Paoletti

Journal:

British Journal of Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 432 KB

english, 2009

10

The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: Implications for clinical use

Charles H. Large, David M. Sokal, Astrid Nehlig, Martin J. Gunthorpe, Raman Sankar, Christopher S. Crean, Kevan E. VanLandingham, H. Steve White

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 262 KB

english, 2012

11

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

Davis, John B., Gray, Julie, Gunthorpe, Martin J., Hatcher, Jonathan P., Davey, Phil T., Overend, Philip, Harries, Mark H., Latcham, Judi, Clapham, Colin, Atkinson, Kirsty

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 305 KB

english, 2000

12

Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway

Martin J. Gunthorpe, Boris A. Chizh

Journal:

Drug Discovery Today

Année:

2009

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2009

13

TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation

Sarah C. Lappin, Andrew D. Randall, Martin J. Gunthorpe, Valerie Morisset

Journal:

European Journal of Pharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 435 KB

english, 2006

14

Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology

Darren Smart, Jeffrey C Jerman, Martin J Gunthorpe, Stephen J Brough, Jennie Ranson, William Cairns, Philip D Hayes, Andrew D Randall, John B Davis

Journal:

European Journal of Pharmacology

Année:

2001

Langue:

english

Fichier:

PDF, 146 KB

english, 2001

15

TRPV channels as temperature sensors

Christopher D. Benham, Martin J. Gunthorpe, John B. Davis

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 219 KB

english, 2003

16

Ototrauma induces sodium channel plasticity in auditory afferent neurons

Alistair G. Fryatt, Mike Mulheran, Julie Egerton, Martin J. Gunthorpe, Blair D. Grubb

Journal:

Molecular and Cellular Neuroscience

Année:

2011

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2011

17

The diversity in the vanilloid (TRPV) receptor family of ion channels

Martin J. Gunthorpe, Christopher D. Benham, Andrew Randall, John B. Davis

Journal:

Trends in Pharmacological Sciences

Année:

2002

Langue:

english

Fichier:

PDF, 128 KB

english, 2002

18

Cloning and functional expression of a human orthologue of rat vanilloid receptor-1

Philip Hayes, Helen J Meadows, Martin J Gunthorpe, Mark H Harries, D.Malcolm Duckworth, William Cairns, David C Harrison, Catherine E Clarke, Kathryn Ellington, Rab K Prinjha, Amanda J.L Barton, Andre

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 591 KB

english, 2000

19

The therapeutic potential of TRPV1 (VR1) antagonists: clinical answers await

Harshad K. Rami, Martin J. Gunthorpe

Journal:

Drug Discovery Today: Therapeutic Strategies

Année:

2004

Langue:

english

Fichier:

PDF, 190 KB

english, 2004

20

S1665 Attenuation of Inhibitory Responses to Colorectal Distension Within the Thalamus By Alosetron: Role of 5-HT2B vs 5-HT3 Receptors

Woods, Amanda J., Bulmer, David C., Evans, Martyn L., Lowe, Andrew, Gregory, Lloyd J., Gunthorpe, Martin J., Lee, Kevin, Aziz, Qasim, Williams, Steven C., Winchester, Wendy J.

Journal:

Gastroenterology

Année:

2008

Langue:

english

Fichier:

PDF, 87 KB

english, 2008

21

Peripheral TRPV1 Receptors As Targets for Drug Development: New Molecules and Mechanisms

Szallasi, Arpad, Gunthorpe, Martin

Journal:

Current Pharmaceutical Design

Année:

2008

Langue:

english

Fichier:

PDF, 270 KB

english, 2008